Topics AZ Popping Videos. The defining characteristic of KA is that it is dome-shaped, symmetrical, surrounded by a smooth wall of inflamed skin, and capped with keratin scales and debris. Following this, the region usually heals quickly. doi:10.1111/j.1524-4725.2004.30080.x. The pictures show the progression and treatment of a type of skin cancer known as keratoacanthoma,. Usually, this is an area exposed to the sun, such as your head, neck, eyelid, back of the hand, or arm or leg. Casey Gallagher, MD, is board-certified in dermatology. Keratoacanthoma is a dome-shaped lump or tumor that grows on your skin. DermNet provides Google Translate, a free machine translation service. Age: predominantly in patients aged 40-70 years. Skin Cancer Foundation. You are a miracle worker!!!!". This is called Mohs surgery. Keratoacanthomas commonly disappear on their own. However, because it can look very similar to a skin cancer called a squamous cell carcinoma, the most common diagnosis (and treatment) is to remove it surgically and send a tissue sample to Treatment for generalised eruptive keratoacanthoma is unsatisfactory. arrow-right-small-blue The disorder can be managed with the aid of oral medicines like Cyclophosphamide, Methotrexate or Acitretin. Keratoacanthoma (KA) is a rapidly growing skin cancer usually appearing as a volcano-like bump on the sun-exposed skin of middle-aged and elderly individuals. We review current knowledge on the clinical, histopa Grzybowski's Generalized Eruptive Keratoacanthomas in a Patient with Terminal Kidney Disease-An Unmet Medical Need Equally Ameliorated by Topical Imiquimod Cream and Lapacho Tea Wraps: A Case Report. 0 Comments. [2], Many new treatments for melanoma are also known to increase the rate of keratoacanthoma, such as the BRAF inhibitor medications vemurafenib and dabrafenib. In patients with more than one keratoacanthoma, the doctor may suggest taking a pill (isotretinoin) to reduce their size and number. The derm did help the patient curb the cancer from potentially getting worse and/or spreading. In case of a surgical removal, doctors may recommend usage of a broad-spectrum antimicrobial drug or an oral analgesic (such as Metacam or Torbugesic) for relief from post-operative discomforts like pain. Thirdly, a scar resulting from medically treated lesions are better in appearance than those which are allowed to resolve spontaneously. Definition / general. All rights reserved. Topical 5-fluorouracil cream applied three times a day for 1 to 6 weeks has been found to be effective. They can: If you cant have surgery, or if you have multiple keratoacanthomas, you can try other treatments: Its not unusual for a single keratoacanthoma to shrink and disappear on its own after several months. A Comparison of Chromosomal Aberrations by Comparative Genomic Hybridization., Cleveland Clinic Center for Continuing Education: Nonmelanoma Skin Cancer.. A portion of KA can become invasive squamous cell carcinomas if they are not treated. Am J Dermatopathol. Keratoacanthoma usually shows a sharp delineation between the tumor nests and stroma and can entrap elastic fibers. Keratoacanthoma. Freezing with liquid nitrogen (cryosurgery), in which very cold liquid nitrogen is sprayed on the keratoacanthoma, freezing it and destroying it in the process. Two striking features of KA are its clinical behavior with spontaneous regression after rapid growth and its nosological position on the border between benignity and malignancy. If you suspect yourself to be suffering from Keratoacanthoma growths, get in touch with a doctor, dermatologist or plastic surgeon. Treatment of Keratoacanthoma is important for several reasons. The papules usually arise over areas of the body that are exposed to sunlight, such as the face, neck, forearms and the dorsum of hands. Mascitti H, De Masson A, Brunet-Possenti F, et al. Keratoacanthoma is a dome-shaped lump or tumor that grows on your skin. DermNet provides Google Translate, a free machine translation service. The lesions can arise as an effect of sun-exposure. It should be added to the therapeutic armamentarium of all physicians who treat keratoacanthoma. The nodule may grow to up to 2 centimeters in diameter over about 8 weeks before gradually disappearing. These initially look like reddish or skin-colored papules but rapidly develop into dome-like nodules at a later stage. Keratoacanthoma (KA) is a common, rapidly growing, locally destructive skin tumour. This image displays a close-up of a keratoacanthoma. 2016;74(6):122033. 2023 Dotdash Media, Inc. All rights reserved. Keratoacanthomas are considered an epithelial neoplasm. Your doctor will have to remove a large-enough piece so the pathologist can see the shape of the tumor with its distinctive crater. If you have an area appear suddenly and it doesn't go away within a relatively short period of time, please make an appointment to have it looked at. Also, young adults should ask adult family members whether or not they have ever had a skin cancer and relay this information to their physician. The hard lump under skin making you anxious? If untreated, KA's usually stop growing around 6-8 weeks, stay dormant and unchanging for 2-6 weeks, and then finally spontaneously regress slowly over 2 to 12 months frequently healing with scarring. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Smoking Pot Every Day Linked to Heart Risks, Artificial Sweetener Linked to Heart Risks, FDA Authorizes First At-Home Test for COVID and Flu, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox. Books about skin diseasesBooks about the skin Although, in some cases, these can be cup-shaped with some ulceration in the center. Histology of lesions in Grzybowski syndrome, Familial keratoacanthomas of Witten and Zak, Multiple self-healing squamous epitheliomas of Ferguson-Smith, Keratoacanthoma: Epidemiology, risk factors, and diagnosis. Sampling a small piece of skin by using a flexible razor blade, a scalpel, or a tiny cookie cutter (called a punch biopsy). 2014;53(2):1316. These growths are radiosensitive and show a good response to low doses of radiation. They can occur spontaneously or following trauma and have the propensity to regress with time. National Cancer Institute. 0 Likes. Keratoacanthoma and squamous cell carcinoma have similar features, such as actinic damage. We review the current management with an emphasis on treatment. If you have any concerns with your skin or its treatment, see a dermatologist for advice. For example, keratoacanthoma is typically known for its rapid growth, but sometimes a squamous cell carcinoma can follow a similar rapid course, especially if the immune system isn't working correctly. Then, it becomes a smooth dome-shaped lesion with a central core. A common and distinctive feature of KA is a clinical course characterized by phases of rapid growth, lesion stability, and spontaneous involution. Reproduced with permission from DermNet New Zealand www.dermnetnz.org 2023. The provisions of the Bar Council of India, Rules, 1962, does not permit advocates to solicit work or adve This image displays a keratoacanthoma on the lip. Authors: Associate Professor Amanda Oakley, 1999; updated by Katrina Tan, Medical Student, Monash University, Melbourne, Australia; Dr Martin Keefe, Dermatologist, Christchurch, New Zealand. The condition primarily arises in people who are older than 60 years of age. Take a look at these Keratoacanthoma images to know how the lesions caused by this skin disease look like. What Does Basal Cell Carcinoma Look Like? A pathological examination may reveal the presence of squamous cell carcinoma where a dermatological test shows a keratoacanthoma lesion. You may be able to find the same content in another format, or you may be able to find more information, at their web site. 0% 10 Views. away. The condition manifests as a single or multiple hard, round growths over the skin surface. She said to return in a month. Treatment is often unsatisfactory. Squamous Cell Carcinoma is a cancerous skin condition that highly resembles Keratoacanthoma lesions. The incidence rate in Queensland, Australia is 409/100,000 person-years. Medical treatment is usually set aside for cases where it is not possible to carry out surgical intervention. Keratoacanthoma is a squamoproliferative lesion of unknown cause that occurs chiefly on sun-exposed skin and, far less commonly, at the mucocutaneous junction. KA papules grow rapidly and have a dry core in the middle. Copy edited by Gus Mitchell. Dermatopathology. The cause of keratoacanthoma is unknown. It a low grade epidermal growth that arises from the hair follicle and has a quick progression. Its also important to protect your skin from sun damage. In pure Dr. Pimple Popper fashion, the second photo takes gore to a whole new level, showing a seemingly gaping, bloody hole that's exposing the mushy flesh typically hiding under the patient's skin. Keratoacanthomas are sharply demarcated, firm, erythematous or skin-coloured, with a classic central hyperkeratotic plug and an even shoulder. 2015;28(6):799-806. doi:10.1038/modpathol.2015.5. For lesions that are entirely resected, can diagnose as "well differentiated squamous cell carcinoma, keratoacanthoma type". It is more common with individuals having an increased degree of sun exposure and is often found at sites of previous injury or trauma. Savage JA, Maize JC, Sr. Keratoacanthoma clinical behavior: a systematic review. Potato Pat's Mystery Bump Removal - Possible Keratoacanthoma. It most frequently occurs on the sun exposed skin of the head and neck, arms and legs and is more common in fair sun-damaged individuals or people whose immune system is suppressed by disease or treatment (such as transplant patients). The first one is proliferative stage. Keratoacanthoma is regarded as benign and thus has an excellent prognosis following surgical excision. This image displays a larger keratoacanthoma occurring in a skin fold. Most keratoacanthoma cause only minimal skin destruction, but a few behave more aggressively and can spread to lymph nodes. You can usually find an acanthoma lesion on areas of the body that are exposed to the sun, such as the face, trunk, arms, or legs. In general, KA is considered a low grade or well-differentiated type of squamous cell carcinoma; however, it tends to grow rapidly over a few weeks to months, locally invading surrounding tissues. Typically, a solitary KA grows larger than 2cm. Keratoacanthoma# These are small skin tumors that grow under your skin with a keratin . It was first described in 1950 and around 40 cases have been reported since. High-risk features for local recurrence and the development of metastatic disease include >2 mm thickness; Clark level higher than IV; perineural invasion; lip or ear as primary site; poorly or undifferentiated tumor. Keratoacanthoma (KA) is a low-grade, or slow-growing, skin cancer tumor that looks like a tiny dome or crater. Sometimes these can clinically mimic each other. In some cases, they may leave a scar. The nodules usually resolve naturally within a few weeks or months (Spontaneous Involution). doi:10.1001/jamadermatol.2020.4097. KAs may regress spontaneously with scarring, but clinically they may be indistinguishable from well-differentiated squamous cell carcinoma (SCC) and the clinical course may be unpredictable. The ICD9 Code for Keratoacanthoma is 238.2. While a keratoacanthoma lesion may stand out, the good news is that these are usually noncancerous and will often go away on their own. Most patients are over 60 years of age and it is twice as common in males than in females. Genetic factors are believed to be involved in the development of some forms of multiple Keratoacanthoma that are found to affect several members of the same family. Follow-up would be required to monitor for recurrence of disease. The cells of keratoacanthoma often look just like those of squamous cell carcinoma. The etiology is unknown. Most keratoacanthoma are painless, though some may be itchy. Its the most precise way to get rid of keratoacanthoma but also the most expensive. November 2021. In most patients, the nodules go away in 4-6 months. permitted to modify, publish, transmit, participate in the transfer or sale, create derivative works, or in any way exploit any of the content, in whole or in part. Its rare for anyone under age 20 to have keratoacanthoma. Histologic subtypes include spindle-cell, acantholytic, verrucous, and desmoplastic SCCs, and keratoacanthoma. Keratoacanthoma. Especially in more cosmetically-sensitive areas, and where the clinical diagnosis is reasonably certain, alternatives to surgery may include no treatment (awaiting spontaneous resolution). While there are always some very loud haters on social media, lots of the comments on Dr. Pimple Popper's post are applauding her A+ job: "Amazing work as always," "Wow. Havenith R, de Vos L, Frhlich A, et al. Keratoacanthomas are round, firm, usually flesh-colored nodules with sharply sloping borders and a characteristic central crater containing keratinous material; they usually resolve spontaneously, but some may be a well-differentiated form of squamous cell carcinoma. Remove one layer of tissue at a time and examine each one under a microscope to make sure all abnormal cells are gone. Systemic retinoids (such as Isotretinoin), 5-fluorouracil, steroids, bleomycin and intralesional methotrexate have been found to yield some success in treating the condition. Starting as a small, pimple-like lesion, a keratoacanthoma typically develops into a dome-shaped, skin-colored nodule with a central depression filled with keratin (the major protein found in hair, skin, and nails). These growths may be divided into several types, such as: It is a Keratoacanthoma variant which is characterized by lesions that sometimes grow several centimeters in size. In some patients, a large growth is removed by radiotherapy, which requires several visits over a period of days. Dermatologists often mistake this condition for a benign Keratoacanthoma which can be dangerous for patients. Once you spot it, its important to talk to your doctor. Treatments that may be considered include: Generalised eruptive keratoacanthomas are frequently progressive and chronic. In selected cases, experienced clinicians may consider other options, such as: Samples for histology will be absent or may be imperfect, but the above techniques may be deemed suitable after considering the size and location of the tumour, the overall health of the patient and the likely morbidity from surgery. The procedure involves: Once the diagnosis of keratoacanthoma is established, the treatment options usually include: Very rarely, keratoacanthoma are treated with medicine injected directly into the skin lesion (intralesional chemotherapy). The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. 2010; 32(5):4236. The nodules usually have a smooth shiny surface. Multiple lesions of this type are also seen in patients of Grzybowski eruptive keratoacanthoma. There are a few different surgeries your doctor may use. Domed papule on the finger with the typical central plug in generalised eruptive keratoacanthomas The classic keratoacanthoma has a crateriform appearance when viewed histologically at low power. This can be true even if the trauma is too small or negligible for the patient. A surgeon can numb the area and excise the lesion using a scalpel. Squamous cell carcinoma treatment. These are usuall. Dermatol Surg. A dermatofibroma is a hard bump that generally forms on an arm or leg in a spot where the skin has been damaged in some way (perhaps bitten by a bug or stuck by a thorn), but in many cases, it's. Grzybowski syndrome is even more rare. It is not associated with internal malignancy, except in rare instances where multiple keratoacanthomas are associated with a disease process called, Roger C. Byrd, DO Clinical Manuscript Competition, Dermatopathology of Summer Skin Conditions, Update on Eczema: Focus on Atopic Dermatitis, 2022 Fall Conference Newsletter Is Available, AOCD Board of Trustees Pens Letter to ABD Regarding Certification Recognition, AOCD Thursday Bulletin for September 16, 2021, AOCD Thursday Bulletin for August 12, 2021, AOCD 2024 Spring New Trends in Dermatology, AOCD 2025 Spring New Trends in Dermatology. It is more common with individuals having an increased degree of sun exposure and is often found at sites of previous injury or trauma. Proper diagnosis and timely treatment can help you avoid discomforting symptoms as well as potential cancerous complications from this disorder. It lasts for two or three months when they grow rapidly and in this phase it can be mixed up with squamous cell carcinoma. KA lumps arise as small, hard papules on the skin surface. Admin. Identifying & Treating Skin Cancer on the Face, When to Worry vs. Not Worry About Lumps Under Your Skin, Pictures of Actinic Keratosis, Moles, Nevus, and Psoriasis, Clear cell acanthoma: a review of clinical and histologic variants, Melanoacanthoma: uncommon presentation of an uncommon condition, Keratoacanthoma and squamous cell carcinoma are distinct from a molecular perspective, Rapid growth rate is associated with poor prognosis in cutaneous squamous cell carcinoma. Freedberg, Irwin M., ed. Classically, a KA manifests as a rapidly growing, well-differentiated, squamoid lesion with a predilection for sun-exposed sites in elderly people and a tendency to spontaneously regress. DermNet does not provide an online consultation service. Once youve had one keratoacanthoma, you may be more likely to get others in the future. It is not associated with internal malignancy, except in rare instances where multiple keratoacanthomas are associated with a disease process called Muir-Torre syndrome. It usually happens in abnormal circumstances when there is multiplication of cells in the hair follicle which in turn leads to the growth of a cellular mass into a Keratoacanthoma. Complete excision is the preferred mode of treatment for all skin neoplasms that are suspected to be Keratoacanthoma lesions. 2021; 46(7): 13768. Therefore, prompt diagnosis and treatment are recommended. These are extremely itchy in nature and may cause severe deformity. Early diagnosis is needed to differentiate a keratoacanthoma from a skin cancer called squamous cell carcinoma (SCC). If left untreated, a true keratoacanthoma can continue to grow for several months. They commonly stop growing and slowly shrink away after two months to a year. Abbas MN, Tan WS, Kichenadasse G. Sorafenib-related generalized eruptive keratoacanthomas (Grzybowski syndrome): acase report. Keratoacanthoma. On this Wikipedia the language links are at the top of the page across from the article title. [14], If the entire lesion is removed, the pathologist will probably be able to differentiate between keratoacanthoma and squamous cell carcinoma. 2001; 142:800-803. doi:10.1046/j.1365-2133.2000.03430.x. Keratoacanthoma. BRB, gagging, but also can't. BJD. KA is benign despite its similarities to squamous cell carcinoma (SCC), or the. These tend to come off in about 2 weeks, though lesions on limbs can take a longer time. thurgood marshall school of law apparel Projetos; bubble buster 2048 town Blog; cell defense the plasma membrane answer key step 13 Quem somos; how to make a good elder scrolls: legends deck Contato The specific pathogenetic mechanisms are unclear but may involve aberrant regulation of the WNT signal transduction pathways and mutations in the tumour suppression gene TP53. If that does not happen, surgical intervention can be necessary. For this reason, a Deep Incisional or Excisional biopsy is needed for detection of the disease. Although KAs can spontaneously involute, dermatologists typically treat them because of their uncertain behavior, potential for local tissue . Squamous cell carcinoma arising in keratoacanthoma: a neglected phenomenon in the elderly. Int J Dermatol. It is found to arise in individuals suffering from Ferguson-Smith familial keratoacanthoma, a condition that is seen to be more common in men. Epidermolytic acanthoma: a case report. doi:10.1111/bjd.20389. Keratoacanthoma is most commonly seen in elderly, light-skinned people with a history of sun exposure. If you dont treat it, keratoacanthoma can spread throughout your body. Your IP address is listed in our blacklist and blocked from completing this request. This may result in an infection or lead the lump to just get larger." Hard lumps on skin can be caused due to multiple factors, some benign and some malignant. A keratoacanthoma appears on sun-damaged skin and typically has a red, firm base and central crust-like ?plug.? Surgery helps remove or resolve these lesions with minimal or no scarring. Generalized eruptive keratoacanthomas of Grzybowski. Dermatol Ther (Heidelb). Most cases are seen in older adults. June 7, 2022; privateer 141 vs commencal meta tr . The disease may also occur due to carcinogens (chemical substances that give rise to cancer). Domed, centrally plugged papules on the face in generalised eruptive keratoacanthomas Depending on the site of involvement, keratoacanthoma may interfere with normal function of the affected area. Clin Dermatol. JAMA Dermatol. The medical information provided in this site is for educational purposes only and is the property of the American Osteopathic College of Dermatology. Hyperkeratotic lesions on the legs in generalised eruptive keratoacanthomas Any use, re-creation, dissemination, forwarding or copying of this information is strictly prohibited unless expressed written permission is given by the American Osteopathic College of Dermatology. The growth was not life-threatening. Its a condition you can get through your genes and may start as early as age 8. This is called. Keratoacanthoma Incidence This skin disease is said to affect one out of every 1,000 individuals. Mohs micrographic surgery, in which the physician takes tiny slivers of skin from the cancer site until it is completely removed. Finally, it is important to remember that treatment of keratoacanthoma is not complete once the skin cancer has been removed. : a rapidly growing skin tumor that occurs especially in elderly individuals, resembles a carcinoma of squamous epithelial cells but does not spread, and tends to heal spontaneously with some scarring if left untreated Dictionary Entries Near keratoacanthoma keratitis punctata keratoacanthoma keratocele See More Nearby Entries Cite this Entry Style American Osteopathic College of Dermatology. James Spencer, MD, dermatologist in private practice in St. Petersburg, FL, and clinical professor of dermatology at Mount Sinai School of Medicine. Use of photodynamic therapy and acitretin in generalized eruptive keratoacanthoma of Grzybowski. 1993. pp. If you decide to have it removed, you will have various options. Mucosal involvement in Grzybowski syndrome. Lesions on the face may be extensive. However, the unsightly nodule is often surgically removed. Ronald Davis, MD, dermatologist in private practice; adjunct professor of dermatology, University of Texas Medical School San Antonio. It is characterized by the growth of lesions that can sometimes be as many as hundred or more in number. These lesions also apparently arise from a single hair follicle in the neck. Verywell Health's content is for informational and educational purposes only. Radiation therapy can be applied to the lesion. 2016;25(2):8591. DermNet does not provide an online consultation service. Other differential diagnoses include: Most keratoacanthomas are treated surgically. The keratoacanthoma (KA) is a relatively common tumor which most often occurs on the sun-exposed areas of light skinned individuals of middle age and older. For more details, see our Privacy Policy. [2][3] It is rarely found at a mucocutaneous junction or on mucous membranes. Am J Dermatopathol. Thank you, {{form.email}}, for signing up. Keratoacanthoma: a clinico-pathologic enigma. Use of this site constitutes acceptance of Skinsights terms of service and privacy policy. Keratoacanthoma arises from the infundibulum of the hair follicle. The condition can be accurately diagnosed by pathological examination and biopsy. Middle-aged and older adults with fair complexions are most frequently affected [ 2 ]. Its similarity in appearance with more aggressive forms of skin cancer often causes it to be misdiagnosed. There can be so many that doctors cant remove them all with surgery. Few health-related issues cause greater instantaneous anxiety and fear than suddenly discovering something new and unsightly on our skin. However, an antimicrobial ointment may provide soothing sensations if the adjacent tissue is found to be irritated, inflamed or cracked. 2020;156(12):132432. In order to differentiate between the two, almost the entire structure needs to be removed and examined. Keratoacanthoma (KA) is a well differentiated, cutaneous squamous cell carcinoma, which often spontaneously regresses. Dr. Pimple Popper's caption explains: "I did Mohs micrographic skin cancer surgery on this area to ensure complete removal and sutured the area to create a linear scar (primary closure).". Secondly, the unsightly appearance of the lesion may be worrisome for a patient. The result of the infection is usually a benign, mild skin disease characterized by lesions (growths) that may appear anywhere on the body. In this review, we summarize the clinical and histological features of this not uncommon tumor. Keratoacanthoma (KA) is a growth that is relatively common, benign, and most commonly found in elderly light-skinned individuals. These conditions are extremely rare, but they can cause multiple keratoacanthomas to grow on your skin. It is usually best to assume a KA-like lesion is an SCC and to manage accordingly in line with local or national guidance, until proven otherwise. Let us look at what some of these causes are: . arrow-right-small-blue Keratoacanthoma. Keratoacanthoma is a tumor that is seen on a regular basis in a dermatologic and dermato-oncologic practice. 10/13/2022Fall 2022 Newsletter Is Available, 7/19/20222022 Fall Conference Newsletter Is Available, 7/5/2022Summer 2022 Newsletter Is Available, 4/4/2022Spring 2022 Newsletter Is Available, 12/21/2021Winter 2021 Newsletter Is Available, 12/7/2021AOCD Board of Trustees Pens Letter to ABD Regarding Certification Recognition, 10/19/2021Fall 2021 Newsletter Is Available, 9/16/2021AOCD Thursday Bulletin for September 16, 2021, 8/12/2021AOCD Thursday Bulletin for August 12, 2021, 7/22/2021AOCD Thursday Bulletin for July 22, 2021, 7/15/2021AOCD Thursday Bulletin for July 15, 2021, 7/8/2021AOCD Thursday Bulletin for July 8, 2021, 4/10/2024 4/14/2024AOCD 2024 Spring New Trends in Dermatology, 2/17/2025 2/23/2025AOCD 2025 Spring New Trends in Dermatology, 2902 North Baltimore Street | P.O. Keratocanthoma. 2005 - 2023 WebMD LLC. Anzalone CL, Cohen PR. If you see or feel anything that doesn't look, well, right or feels different, get it checked out. [4][12] Although HPV has been suggested as a causal factor, it is unproven. Excellent results have been reported with 5-fluorouracil injections. The cause of generalised eruptive keratoacanthomas is not completely understood but they have been associated with: Generalised eruptive keratoacanthomas present as a sudden or progressive eruption of hundreds to thousands of small (15mm), pruritic, umbilicated, skin-coloured to erythematous papules, with a central keratotic plug. Also known as Solitary Keratoacanthoma, these are benign but locally aggressive lesions that grow rapidly. Firstly, it is not always easy for doctors to make sure that a lesion is a keratoacanthoma and not some form of skin cancer. This technique is especially useful for large rapidly growing KA's. Unfortunately, dermoscopy cannot reliably discriminate KA from SCC. You may develop just one, or less commonly, you can have several. In addition, good sun protection habits (see the above Self-Care section) are vital to preventing further damage from UV light. In rare cases, however, it progresses to metastatic or invasive cases of carcinoma. Karaa A, Khachemoune A. Keratoacanthoma: a tumor in search of a classification. 18 Clinically, keratoacanthoma typically presents as a flesh-coloured, dome-shaped nodule with a prominent central keratinous plug, with the characteristic history of rapid Number of pages. 29. There is no online registration for the intro class Terms of usage & Conditions Other possible causes can include: You may visit your healthcare provider when you note symptoms of keratoacanthoma, and they may refer you to a dermatologist (a specialist in skin conditions).